Letrozole is a medication primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. It functions as an aromatase inhibitor, which means it helps lower estrogen levels in the body. By reducing estrogen, letrozole slows the growth of certain breast tumors that require this hormone to grow.
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How Does Letrozole Work?
Letrozole works by inhibiting the aromatase enzyme, which is responsible for converting androgens into estrogens in the body. When estrogen levels are decreased, it can lead to an environment that is less conducive to the growth of hormone-sensitive tumors. This mechanism makes letrozole an essential component in certain cancer treatment regimens.
Uses of Letrozole
Besides its primary use in breast cancer treatment, letrozole has other applications, including:
- Ovulation induction in women with polycystic ovary syndrome (PCOS).
- Treatment of infertility in women who do not respond to other fertility medications.
- Off-label use by some athletes for bodybuilding and performance enhancement purposes.
Possible Side Effects
While letrozole can be effective, it may also come with side effects. Common side effects include:
- Hot flashes
- Joint pain
- Fatigue
- Nausea
- Bone density loss
Conclusion
Letrozole is a vital medication in the fight against certain types of breast cancer, offering hope to many patients. However, its use should always be under the guidance of a healthcare professional to manage potential side effects and to ensure its appropriateness for each individual case.